1-Hydroxybenzotriazole → HCID 15552330, compound

Participants

Reaction Steps

To a solution of 1-(4-aminophenyl)imidazole(0.71 g), 4-phenyl 4-(3,5,6-trimethyl-1,4-benzoquinon-2-yl)butanoic acid(1.25 g), ,1-(3-dimethylaminopropyl)-3-ethylcarbodiimide hydrochloride(0.85 g) and 1-hydroxybenzotriazole(0.85g) in DMF(8 ml) was added triethylamine(0.7 ml) and the mixture was stirred at room temperature for 20 hours. The reaction mixture was poured into ice water and the precipitate was filtered and dissolved in chloroform-methanol. This solution was washed with brine, dried (MgSO4) and evaporated to dryness. The residue was purified by column chromatography on silica gel (chloroform: methanol=100:3) to obtain the title compound (0.82 g, amorphous).

Provenance & Evidence