2-(Methylamino)ethanol → 2-chloro-4-methyl-6-(N-methyl-2-hydroxyethylamino)pyrimidine

Beteiligte Stoffe

Reaktionsschritte

Part A: A solution of 2,4-dichloro-6-methylpyrimidine (1.0 g) and 2-(methylamino)ethanol (0.4 g) in ethanol (50 mL) was refluxed for 24 hours. The solvent was evaporated to give a crude residue, which was chromatographed on silica gel using 5% methanol in chloroform to yield 2-chloro-4-methyl-6-(N-methyl-2-hydroxyethylamino)pyrimidine (370 mg).

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