2-Chloro-4,6-dimethylpyrimidine → N-[3-bromo-5-methyl-pyridin-2-yl]-4,6-dimethyl-2-pyrimidinamine

Participants

Role	Name	HCID	Charge
Reactant	2-Chloro-4,6-dimethylpyrimidine	HCID 20550	—
Reactant	Sodium hydride	HCID 24758	—
Reactant	2-Amino-3-bromo-5-methylpyridine	HCID 519380	—
Solvent	Dimethylformamide	HCID 6228	—
Product	N-[3-bromo-5-methyl-pyridin-2-yl]-4,6-dimethyl-2-pyrimidinamine	HCID 18323693	—

Reaction Steps

Part A: A 1.0 gram (5.35 mmol) portion of commercially available 2-amino-3-bromo-5-methylpyridine was coupled to 2-chloro-4,6-dimethylpyrimidine (Example 1; part A) using NaH (1.2 eq) in DMF to give N-[3-bromo-5-methyl-pyridin-2-yl]-4,6-dimethyl-2-pyrimidinamine. C12H13N4Br MS 293 (M+H)+.

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US06342503B1
Source dataset	uspto-grants-2002_01
ORD ID	ord-d0d7ad7d02b24d16b962d4069d8984af
Source note	uspto-grants-2002_01