Ammonia → HCID 18426773, compound

HRID 1251553Notes

Reaction equation

HRID 1251553 reaction equation
[Cl:1][C:2]1[CH:3]=[C:4]([C:9]2([CH2:17][CH2:18][C:19]([OH:21])=[O:20])[CH2:14][CH2:13][C:12](=[O:15])[NH:11][C:10]2=[O:16])[CH:5]=[CH:6][C:7]=1[Cl:8].[NH3:22]>>[C:10]([C:9]([C:4]1[CH:5]=[CH:6][C:7]([Cl:8])=[C:2]([Cl:1])[CH:3]=1)([CH2:14][CH2:13][C:12](=[O:15])[NH2:11])[CH2:17][CH2:18][C:19]([OH:21])=[O:20])(=[O:16])[NH2:22]

Participants

3

Reactant 2

HCID 222AmmoniaHCID 11121055HCID 11121055, compound

Product 1

HCID 18426773HCID 18426773, compound

Procedure

3.30 g of racemic 3-(3,4-dichlorophenyl)-2,6-dioxopiperidine-3-propionic acid are placed in 20 ml of an aqueous solution of aqueous ammonia at 30% and stirred at room temperature. After 2 hours, the solution is degassed under vacuum to remove the excess aqueous ammonia and then diluted to 50 ml with water. The medium is slowly acidified to pH 2-3 with 1 N HCl. The precipitate formed is filtered, drained and then dried over KOH to give 3.13 g of the expected compound.

Workup

  1. customthe solution is degassed under vacuum
  2. customto remove the excess aqueous ammonia
  3. additiondiluted to 50 ml with water
  4. customThe precipitate formed
  5. filtrationis filtered
  6. dry with materialdried over KOH

Sources & evidence

ORD record
ord-3bfe2da205284e43b28edc2afeda673f
Source dataset
uspto-grants-2002_01
Patent number
US06342607B1

Reaction notes

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