Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Dimethylformamide | HCID 6228 | — |
| Reactant | Thionyl Chloride | HCID 24386 | — |
| Reactant | HCID 11121055 | HCID 11121055 | — |
| Solvent | Toluene | HCID 1140 | — |
| Product | HCID 88151707 | HCID 88151707 | — |
Reaction Steps
Under a nitrogen atmosphere, 20 g of 3-[3-(3,4-dichlorophenyl)-2,6-dioxopiperidin-3-yl]propionic acid, 200 ml of toluere and 0.5 ml of DMF are mixed. The medium is heated to 60° C and 14.9 g of thionyl chloride and 40 ml of toluene are introduced dropwise. The stirring is maintained for 5 hours at 60° C. The toluene and the excess thionyl chloride are evaporated off and then the reaction medium is dried in an oven (40° C.) overnight.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US06342607B1 |
|---|
| Source dataset | uspto-grants-2002_01 |
|---|
| ORD ID | ord-fe6be355b784419d90ecaa649ce00bc0 |
|---|
| Source note | uspto-grants-2002_01 |
|---|
