Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Piperitenone → Pulegol
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Piperitenone | HCID 381152 | — |
| 반응물 | 4,4'-Bi-1,3-benzodioxole-5,5'-diylbis{bis[4-methoxy-3,5-bis(2-methyl-2-propanyl)phenyl]phosphine} | HCID 11194192 | — |
| 반응물 | HCID 178418361 | HCID 178418361 | — |
| 용매 | Ethyl Acetate | HCID 8857 | — |
| 생성물 | Pulegol | HCID 92793 | 90% |
반응 단계
A 500 ml capacity autoclave was charged with 150 g (1 mol) of piperitenone, 18.6 mg (0.04 mmol) of [Rh(cod)2]PF6, 47.2 mg (0.04 mmol) of (S)-DTBM-SEGPHOS, 14.8 mg (0.02 mmol) of BrPPh3(CH2)4PPh3Br and 7.5 ml of ethyl acetate, and the reaction was carried out at 50° C. for 20 hours under a hydrogen pressure of 3 Mpa. After completion of the reaction, hydrogen was purged, the reaction solution was concentrated and then distillation was carried out under a reduced pressure to obtain 136.8 g of pulegol. The yield was 90%.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US06342644B1 |
| 출처 데이터셋 | uspto-grants-2002_01 |
| ORD ID | ord-f11ee04b83614e508217b5832ddca314 |
| 출처 메모 | uspto-grants-2002_01 |