HuagongsheHuagongshe Chemistry Print Report · For research reference only
Benzyloxycarbonyl-L-proline → (S)-tert-butyl 1-((S)-pyrrolidine-2-carbonyl)pyrrolidine-2-carboxylate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Benzyloxycarbonyl-L-proline | HCID 101987 | — |
| Reactant | tert-Butyl L-prolinate hydrochloride | HCID 6453107 | — |
| Product | (S)-tert-butyl 1-((S)-pyrrolidine-2-carbonyl)pyrrolidine-2-carboxylate | HCID 15598548 | 99.4% |
Reaction Steps
A] Starting from H-Pro-OtBu.HCl (0.315 g, 1.5 mmoles) and Z-Pro-OH (0.397 g, 1.59 mmoles) the procedure of Example 1, C-D] was substantially applied. There was obtained 0.4 g of H-Pro-Pro-OtBu.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06342481B1 |
| Source dataset | uspto-grants-2002_01 |
| ORD ID | ord-b1fc3be1e53f468b97ba902c17a8a3e0 |
| Source note | uspto-grants-2002_01 |