Hydrochloric Acid → HCID 131723106, compound

Participants

Reaction Steps

10% Pd/C (150 mg) was added to a solution of N-((phenylmethoxy)-carbonyl]glycine[2-(dioctadecylamino)-2-oxoethyl] ester (1.2 g; 1.4 mmol) in EtOAc (100 mL) and the suspension was stirred for 3 h under hydrogen atmosphere at room temperature. After filtration (through a Millipore® filter FT 0.45 μm) 1.2 M HCl in MeOH (1.3 mL; 1.6 mmol) was added dropwise to the resulting solution obtaining the precipitation of a white solid that was filtered to give the desired compound (830 mg; 1.2 mmol). Yield 86%. HPLC: 100% (area %). K.F.: 0.22%. The MS and IR spectra were consistent with the structure.

Provenance & Evidence