5-Bromothiophene-2-sulfonyl chloride → N-(4-Bromo-3-methyl-5-isoxazolyl)-5-bromothiophene-2-sulfonamide

HRID 1251659노트

반응식

HRID 1251659 반응식
[NH2:1][C:2]1[O:6][N:5]=[C:4]([CH3:7])[C:3]=1[Br:8].[Br:9][C:10]1[S:14][C:13]([S:15](Cl)(=[O:17])=[O:16])=[CH:12][CH:11]=1>>[Br:8][C:3]1[C:4]([CH3:7])=[N:5][O:6][C:2]=1[NH:1][S:15]([C:13]1[S:14][C:10]([Br:9])=[CH:11][CH:12]=1)(=[O:17])=[O:16]

참가 물질

3

반응물 2

HCID 27339245-Bromothiophene-2-sulfonyl chlorideHCID 104875194-Bromo-3-methylisoxazol-5-amine

생성물 1

HCID 23445555N-(4-Bromo-3-methyl-5-isoxazolyl)-5-bromothiophene-2-sulfonamide수율 30%

실험 절차

N-(4-Bromo-3-methyl-5-isoxazolyl)-5-bromothiophene-2-sulfonamide was prepared in the same manner as described in Example 2 from 5-amino-4-bromo-3-methylisoxazole and 5-bromothiophene-2-sulfonyl chloride in 30% yield. Purification was achieved by recrystallization from ethyl acetate/hexanes to give a crystalline solid, m.p. 240° C. (dec).

후처리

  1. customPurification
  2. customwas achieved by recrystallization from ethyl acetate/hexanes
  3. customto give a crystalline solid, m.p. 240° C. (dec)

출처 및 근거

ORD 기록
ord-67bd8d25c8fb4500bb88d1113399b72d
출처 데이터셋
uspto-grants-2002_01
특허 번호
US06342610B2

반응 노트

불러오는 중…