HuagongsheHuagongshe Chemistry Print Report · For research reference only
Thiophene-3-sulfonyl Chloride → N-(4-bromo-3-methyl-5-isoxazolyl)thiophene-3-sulfonamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Thiophene-3-sulfonyl Chloride | HCID 2776378 | — |
| Reactant | 4-Bromo-3-methylisoxazol-5-amine | HCID 10487519 | — |
| Product | N-(4-bromo-3-methyl-5-isoxazolyl)thiophene-3-sulfonamide | HCID 12146375 | 22% |
Reaction Steps
N-(4-bromo-3-methyl-5-isoxazolyl)thiophene-3-sulfonamide was prepared in the same manner as described in Example 2 from thiophene-3-sulfonyl chloride with 5-amino-4-bromo-3-methylisoxazole in 22% yield. Purification by column chromatography using 10% MeOH/CHCl3 as eluent gave a pale brown oil.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06342610B2 |
| Source dataset | uspto-grants-2002_01 |
| ORD ID | ord-79a2cfc827344240aee2bc99c715430a |
| Source note | uspto-grants-2002_01 |