Methyl 3,5-dimethyl-4-nitrobenzoate → Benzoic acid, 4-amino-3,5-dimethyl-, methyl ester

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Reaction Steps

4-carbomethoxy-2,6-dimethylnitrobenzene (2 g, 9.5 mmol) was dissolved in ethyl acetate (20 ml) and subjected to catalytic hydrogenation using 10% palladium on carbon (300 mg) at 55 psi for 30 min. The catalyst was filtered and solvent removed to give 4-carbomethoxy-2,6-dimethylaniline as a solid (1.7 g, 100% yield).

Provenance & Evidence