HuagongsheHuagongshe Chemistry Print Report · For research reference only
(1,1'-Biphenyl)-4-sulphonyl chloride → N-(4-bromo-5-methyl-3-isoxazolyl)-4-biphenylsulfonamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | (1,1'-Biphenyl)-4-sulphonyl chloride | HCID 74192 | — |
| Reactant | 4-Bromo-5-methyl-1,2-oxazol-3-amine | HCID 2774464 | — |
| Product | N-(4-bromo-5-methyl-3-isoxazolyl)-4-biphenylsulfonamide | HCID 15453175 | — |
Reaction Steps
N-(4-bromo-5-methyl-3-isoxazolyl)-4-biphenylsulfonamide was prepared, using the method in Example 193b, from 3-amino-4-bromo-5-methylisoxazole and 4-biphenylsulfonyl chloride in 5% yield. The crude product was purified by column chromatography. After recrystallization from ethyl acetate/hexanes, N-(4-bromo-5-methyl-3-isoxazolyl)-4-biphenylsulfonamide (m.p. 154-156° C.) was obtained in 51% yield.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06342610B2 |
| Source dataset | uspto-grants-2002_01 |
| ORD ID | ord-9d92cb55da304307b06e6a6fccff8956 |
| Source note | uspto-grants-2002_01 |