HCID 18324422, compound → HCID 86585133, compound

HRID 1251873Notes

Reaction equation

HRID 1251873 reaction equation
[F:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[CH:16]=[C:15]([CH:17]([O:25][CH2:26][CH2:27][N:28]3[CH:32]=[CH:31][N:30]=[CH:29]3)[C:18]3[CH:23]=[CH:22][C:21]([F:24])=[CH:20][CH:19]=3)[CH:14]=[CH:13][C:9]=2[C:10](O)=[O:11])=[CH:4][CH:3]=1.[NH2:33][C@@H:34]([CH2:45][CH2:46][S:47][CH3:48])[C:35]([O:37][CH:38]1[CH2:43][CH2:42][N:41]([CH3:44])[CH2:40][CH2:39]1)=[O:36]>>[F:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[CH:16]=[C:15]([CH:17]([O:25][CH2:26][CH2:27][N:28]3[CH:32]=[CH:31][N:30]=[CH:29]3)[C:18]3[CH:23]=[CH:22][C:21]([F:24])=[CH:20][CH:19]=3)[CH:14]=[CH:13][C:9]=2[C:10]([NH:33][C@@H:34]([CH2:45][CH2:46][S:47][CH3:48])[C:35]([O:37][CH:38]2[CH2:39][CH2:40][N:41]([CH3:44])[CH2:42][CH2:43]2)=[O:36])=[O:11])=[CH:4][CH:3]=1

Participants

3

Reactant 2

HCID 18324422HCID 18324422, compoundHCID 53639334HCID 53639334, compound

Product 1

HCID 86585133HCID 86585133, compoundYield 72.5%

Procedure

The title compound was prepared from 2-(4-fluorophenyl)-4-[1-(4-fluorophenyl)-2-(imidazol-1-yl)ethoxymethyl]benzoic acid by a similar method to that used for Example 1 but using N-methylpiperidin-4-yl (2S)-2-amino-4-(methylsulfanyl)butanoate (L-methionine (N-methylpiperidin-4-yl)ester) in place of L-methionine methyl ester.

Sources & evidence

ORD record
ord-ea7a0b2184fb49f58660a83830a3fe3f
Source dataset
uspto-grants-2002_01
Patent number
US06342765B1

Reaction notes

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