Hydrochloric Acid → HCID 18324527, compound

Participants

Reaction Steps

Sodium borohydride (0.41 g; 1.06 mmol) was added portionwise at 0° C. to a solution of 1-(4-fluorobenzoylmethyl)-2-(tert-butyldiphenylsilyloxymethyl)imidazole (4.81 g; 1.01 mmol) in methanol (100 ml). The mixture was stirred at ambient temperature for 16 hours. 12N HCl (0.84 ml) added and then evaporated to dryness and purified by flash column chromatography eluting with dichloromethane/ethanol (96:4) to give 1-[2-(4-fluorophenyl)-2-hydroxyethyl]-2-(tert-butyldiphenylsilyloxymethyl)imidazole.

Provenance & Evidence