Sodium → HCID 18324421, compound

Participants

Reaction Steps

Methyl 2-(4-fluorophenyl)4-{1-(4-fluorophenyl)-2-[2-(tert-butyldiphenylsilyloxymethyl)imidazol-1-yl]ethoxymethyl}benzoate (4 g; 5.58 mmol) in methanol (50 ml) was treated with 2N aqueous sodium hydroxyde solution (5 ml; 11.1 mmol) at 80° C. for 7 hours. After evaporation of the methanol, the residue was taken up in water, the pH adjusted to with 6N HCl and extracted with dichloromethane/ethanol (95/5) to give 2-(4-fluorophenyl)-4-[1-(4-fluorophenyl)-2-(2-hydroxymethylimidazol-1-yl)ethoxymethyl]benzoic acid.

Provenance & Evidence