反应详情

To a solution of methyl 4-methoxy-2-(4-fluorophenyl)benzoate (9.8 g; 0.029 mol) in methanol (75 ml) was added 2N aqueous sodium hydroxide solution (45 ml) and the mixture heated at reflux for 1.5 h. The reaction was cooled to ambient temperature, filtered and the filtrate concentrated in vacuo to remove the methanol. The residual aqueous phase was washed with diethyl ether, acidified to pH 1 with concentrated HCl and extracted with ethyl acetate. The organic extracts were dried (MgSO4) and the solvent removed in vacuo to give 4-methoxy-2-(4-fluorophenyl)benzoic acid as a white solid (7.7 g), which was used without further purification.

1. temperaturethe mixture heated
2. temperatureat reflux for 1.5 h
3. filtrationfiltered
4. concentrationthe filtrate concentrated in vacuo
5. customto remove the methanol
6. washThe residual aqueous phase was washed with diethyl ether
7. extractionextracted with ethyl acetate
8. dry with materialThe organic extracts were dried (MgSO4)
9. customthe solvent removed in vacuo