HuagongsheHuagongshe Chemistry Print Report · For research reference only
5-(1-(4-Fluorophenyl)-2-(imidazol-1-yl)ethoxy)-2-(4-fluorophenethyl)benzoic acid → Cyclopentyl (2S)-2-{5-[1-(4-fluorophenyl)-2-(imidazol-1-yl)ethoxy]-2-(4-fluorophenethyl)benzoylamino}-4-methylsulfanylbutyrate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 5-(1-(4-Fluorophenyl)-2-(imidazol-1-yl)ethoxy)-2-(4-fluorophenethyl)benzoic acid | HCID 18324490 | — |
| Reactant | cyclopentyl (2S)-2-amino-4-(methylsulfanyl)butanoate | HCID 53747326 | — |
| Product | Cyclopentyl (2S)-2-{5-[1-(4-fluorophenyl)-2-(imidazol-1-yl)ethoxy]-2-(4-fluorophenethyl)benzoylamino}-4-methylsulfanylbutyrate | HCID 9895783 | 72% |
Reaction Steps
The title compound was prepared in 72% yield from 5-(1-(4-fluorophenyl)-2-(imidazol-1-yl)ethoxy)-2-(4-fluorophenethyl)benzoic acid and cyclopentyl (2S)-2-amino-4-(methylsulfanyl)butanoate (L-methionine cyclopentyl ester) by a similar method to that used for Example 34.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06342765B1 |
| Source dataset | uspto-grants-2002_01 |
| ORD ID | ord-bea253e633224142b3201a75433732ae |
| Source note | uspto-grants-2002_01 |