Methyl 2-[2-(4-fluorophenyl)ethenyl]-5-methoxybenzoate → Methyl 2-(4-fluorophenethyl)-5-methoxybenzoate

Participants

Reaction Steps

Methyl 2-[2-(4-fluorophenyl)ethenyl]-5-methoxybenzoate (43 g, 150 mmol) in ethyl acetate (3.5L) was stirred with 10% Pd/C (4 g) under an atmosphere of hydrogen (pressure 5 bar), at ambient temperature for 18 hours. The spent catalyst was removed by filtration through a Celite pad, the pad was washed with ethyl acetate and the filtrate evaporated to dryness to give methyl 2-(4-fluorophenethyl)-5-methoxybenzoate (33.8 g, 80% yield).

Provenance & Evidence