HRID1251899

反应详情

EQUATION

反应方程式

REACTANTS

反应物

结构：O=C(O)c1cc(OC(Cn2ccnc2)c2nccs2)ccc1CCc1ccc(F)cc1

HCID18324428

未命名化合物

HCID86585138

未命名化合物

PRODUCTS

生成物

结构：CC(C)(C)OC(=O)[C@H](CCS(C)(=O)=O)NC(=O)c1cc(OC(Cn2ccnc2)c2nccs2)ccc1CCc1ccc(F)cc1

HCID9809803

未命名化合物

收率 75%

PROCEDURE

实验过程

The title compound was prepared in 75% yield from 5-[1-(thiazol-2-yl)-2-(imidazol-1-yl)ethoxy]-2-(4-fluorophenethyl)benzoic acid and L-methionine sulphone tert-butyl ester by similar methodology to that used for Example 40.

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-7a3b9d9193e74c46b41e9d9907c722b6
来源数据集: uspto-grants-2002_01
DOI: 10.6084/m9.figshare.5104873.v1
专利: US06342765B1
来源说明: uspto-grants-2002_01

反应 SMILES

[S:1]1[CH:5]=[CH:4][N:3]=[C:2]1[CH:6]([O:13][C:14]1[CH:15]=[CH:16][C:17]([CH2:23][CH2:24][C:25]2[CH:30]=[CH:29][C:28]([F:31])=[CH:27][CH:26]=2)=[C:18]([CH:22]=1)[C:19](O)=[O:20])[CH2:7][N:8]1[CH:12]=[CH:11][N:10]=[CH:9]1.[NH2:32][C@@H:33]([CH2:41][CH2:42][S:43]([CH3:46])(=[O:45])=[O:44])[C:34]([O:36][C:37]([CH3:40])([CH3:39])[CH3:38])=[O:35]>>[S:1]1[CH:5]=[CH:4][N:3]=[C:2]1[CH:6]([O:13][C:14]1[CH:15]=[CH:16][C:17]([CH2:23][CH2:24][C:25]2[CH:26]=[CH:27][C:28]([F:31])=[CH:29][CH:30]=2)=[C:18]([CH:22]=1)[C:19]([NH:32][C@@H:33]([CH2:41][CH2:42][S:43]([CH3:46])(=[O:45])=[O:44])[C:34]([O:36][C:37]([CH3:39])([CH3:40])[CH3:38])=[O:35])=[O:20])[CH2:7][N:8]1[CH:12]=[CH:11][N:10]=[CH:9]1