1-(4-Fluorophenyl)-2-(1H-imidazol-1-yl)ethanol → Methyl 4-[2-(imidazol-1-yl)-1-(4-fluorophenyl)ethoxy]-2-(4-fluorophenyl)benzoate

HRID 1251904Notes

Reaction equation

HRID 1251904 reaction equation
[F:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[CH:17]=[C:16]([OH:18])[CH:15]=[CH:14][C:9]=2[C:10]([O:12][CH3:13])=[O:11])=[CH:4][CH:3]=1.[N:19]1([CH2:24][CH:25]([C:27]2[CH:32]=[CH:31][C:30]([F:33])=[CH:29][CH:28]=2)O)[CH:23]=[CH:22][N:21]=[CH:20]1>>[N:19]1([CH2:24][CH:25]([C:27]2[CH:32]=[CH:31][C:30]([F:33])=[CH:29][CH:28]=2)[O:18][C:16]2[CH:15]=[CH:14][C:9]([C:10]([O:12][CH3:13])=[O:11])=[C:8]([C:5]3[CH:6]=[CH:7][C:2]([F:1])=[CH:3][CH:4]=3)[CH:17]=2)[CH:23]=[CH:22][N:21]=[CH:20]1

Participants

3

Reactant 2

HCID 127606091-(4-Fluorophenyl)-2-(1H-imidazol-1-yl)ethanolHCID 18324374HCID 18324374, compound

Product 1

HCID 18324444Methyl 4-[2-(imidazol-1-yl)-1-(4-fluorophenyl)ethoxy]-2-(4-fluorophenyl)benzoate

Procedure

Methyl 4-[2-(imidazol-1-yl)-1-(4-fluorophenyl)ethoxy]-2-(4-fluorophenyl)benzoate was prepared from methyl 2-(4-fluorophenyl)-4-hydroxybenzoate and 2-(imidazol-1-yl)-1-(4-fluorophenyl)ethanol using the Mitsunobu reaction as described for the preparation of methyl 5-[2-(2-methylimidazol-1-yl 1-(4-fluorophenyl/ethoxy]-2-(4-fluorophenethyl)benzoate.

Workup

  1. customthe Mitsunobu reaction

Sources & evidence

ORD record
ord-df6aa9addcf7436b955a295025e2db19
Source dataset
uspto-grants-2002_01
Patent number
US06342765B1

Reaction notes

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