1-(4-Fluorophenyl)-2-(1H-imidazol-1-yl)ethanol → Methyl 2-(4-fluorophenyl)-6-[1-(4-fluorophenyl)-2-(imidazol-1-yl)ethoxy]pyridin-3-carboxylate

HRID 1251916Notes

Reaction equation

HRID 1251916 reaction equation
[F:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[C:13]([C:14]([O:16][CH3:17])=[O:15])=[CH:12][CH:11]=[C:10]([OH:18])[N:9]=2)=[CH:4][CH:3]=1.[N:19]1([CH2:24][CH:25]([C:27]2[CH:32]=[CH:31][C:30]([F:33])=[CH:29][CH:28]=2)O)[CH:23]=[CH:22][N:21]=[CH:20]1.FC1C=CC(CCC2C=CC(OC(C3C=CC(F)=CC=3)CC3N(C)C=NC=3)=CC=2C([O-])=O)=CC=1>>[F:1][C:2]1[CH:3]=[CH:4][C:5]([C:8]2[C:13]([C:14]([O:16][CH3:17])=[O:15])=[CH:12][CH:11]=[C:10]([O:18][CH:25]([C:27]3[CH:32]=[CH:31][C:30]([F:33])=[CH:29][CH:28]=3)[CH2:24][N:19]3[CH:23]=[CH:22][N:21]=[CH:20]3)[N:9]=2)=[CH:6][CH:7]=1

Participants

4

Reactant 3

HCID 127606091-(4-Fluorophenyl)-2-(1H-imidazol-1-yl)ethanolHCID 183243882-(4-Fluorophenethyl)-5-[1-(4-fluorophenyl)-2-(1-methylimidazol-5-yl)ethoxy]benzoateHCID 178498306HCID 178498306, compound

Product 1

HCID 18324488Methyl 2-(4-fluorophenyl)-6-[1-(4-fluorophenyl)-2-(imidazol-1-yl)ethoxy]pyridin-3-carboxylate

Procedure

Methyl 2-(4-fluorophenyl)-6-hydroxypyridin-3-carboxylate was reacted with 2-(imidazol-1-yl)-1-(4-fluorophenyl)ethanol by the procedure described for the preparation of 2-(4-fluorophenethyl)-5-[1-(4-fluorophenyl)-2-(1-methylimidazol-5-yl)ethoxy]benzoate to give methyl 2-(4-fluorophenyl)-6-[1-(4-fluorophenyl)-2-(imidazol-1-yl)ethoxy]pyridin-3-carboxylate.

Sources & evidence

ORD record
ord-53b12ded916b422a8d441cd870dfaac9
Source dataset
uspto-grants-2002_01
Patent number
US06342765B1

Reaction notes

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