反应详情

A mixture of methyl 3-(4-fluorophenethyl)-6-[1-(4-fluorophenyl)-2-(1-methylimidazol-5-yl)ethoxy]pyridin-2-carboxylate (1.56 g), sodium hydroxide (0.65 g), water (12 ml) and methanol (80 ml) was heated at reflux for 16 hours and then cooled to ambient temperature. The mixture was concentrated under reduced pressure, 1M citric acid (17 ml) added and the mixture extracted with 10% methanol/dichloromethane (1×50 ml, 2×30 ml). The extracts were dried and concentrated under reduced pressure to give 3-(4-fluorophenethyl)-6-[1-(4-fluorophenyl)-2-(1-methylimidazol-5-yl)ethoxy]pyridin-2-carboxylic acid as a pale yellow foam (1.22 g).

1. temperaturewas heated
2. temperatureat reflux for 16 hours
3. concentrationThe mixture was concentrated under reduced pressure, 1M citric acid (17 ml)
4. additionadded
5. extractionthe mixture extracted with 10% methanol/dichloromethane (1×50 ml, 2×30 ml)
6. customThe extracts were dried
7. concentrationconcentrated under reduced pressure