HuagongsheHuagongshe Chemistry Print Report · For research reference only
1,2-Dichloroethane → N-tert-butoxycarbonyl L-methionine cyclopentyl ester
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 1,2-Dichloroethane | HCID 11 | — |
| Reactant | Cyclopentanol | HCID 7298 | — |
| Reactant | Boc-L-methionine | HCID 89857 | — |
| Catalyst | 4-(Dimethylamino)pyridine | HCID 14284 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | N-tert-butoxycarbonyl L-methionine cyclopentyl ester | HCID 22944441 | — |
Reaction Steps
A mixture of N-tert-butoxycarbonyl L-methionine (30 g.), cyclopentanol (31 g.), DMAP (44 g.), EDC (30 g.) and dichloromethane (200 ml.) was stirred under an inert atmosphere for 16 hours. It was then washed with 1M. aqueous citric acid (200 ml.), saturated sodium carbonate solution (100 ml.) and brine, dried and evaporated to dryness to give N-tert-butoxycarbonyl L-methionine cyclopentyl ester as a gum(36 g.).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06342765B1 |
| Source dataset | uspto-grants-2002_01 |
| ORD ID | ord-a2ab4aa764cd416c8c7a7784204a4104 |
| Source note | uspto-grants-2002_01 |