HuagongsheHuagongshe Chemistry Print Report · For research reference only
Trifluoroacetic acid → cyclopentyl (2S)-2-amino-4-(methylsulfanyl)butanoate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Trifluoroacetic acid | HCID 6422 | — |
| Reactant | Triethylsilane | HCID 12052 | — |
| Reactant | N-tert-butoxycarbonyl L-methionine cyclopentyl ester | HCID 22944441 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | cyclopentyl (2S)-2-amino-4-(methylsulfanyl)butanoate | HCID 53747326 | — |
Reaction Steps
A mixture of N-tert-butoxycarbonyl L-methionine cyclopentyl ester (53 g.), TFA (200 ml.), triethylsilane (39 g.) and dichloromethane (2 L.) was stirred at ambient temperature for 2 hours, evaporated to dryness and then converted to the hydrochloride salt to give L-methionine cyclopentyl ester as a white crystalline solid (40.5 g.).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06342765B1 |
| Source dataset | uspto-grants-2002_01 |
| ORD ID | ord-f1463e8ceb3941ee820aa6cd72768d80 |
| Source note | uspto-grants-2002_01 |