Sodium borohydride → 2-(1-Methylimidazol-5-yl)-1-(thiazol-2-yl)ethanol

Participants

Reaction Steps

Sodium borohydride (0.56 g, 14.9 mmol) was added to a solution of 2-(1-methylimidazol-5-yl)-1-(thiazol-2-yl)ethanone in methanol (150 ml) and the mixture stirred under a nitrogen atmosphere at ambient temperature for 2 hours. The reaction was evaporated to dryness and the resulting gum was treated with water (15 ml) and stirred for 30 minutes to give a solid precipitate which was filtered and dried to give 2-(1-methylimidazol-5-yl)-1-(thiazol-2-yl)ethanol (2.67 g, 95%).

Provenance & Evidence