2-Nitrophenol → 2-(3-Chloro-5-trifluoromethyl-2-pyridyloxy)nitrobenzene

HRID 1252010Notes

Reaction equation

HRID 1252010 reaction equation
[Cl:1][C:2]1[C:3](F)=[N:4][CH:5]=[C:6]([C:8]([F:11])([F:10])[F:9])[CH:7]=1.[N+:13]([C:16]1[CH:21]=[CH:20][CH:19]=[CH:18][C:17]=1[OH:22])([O-:15])=[O:14]>>[Cl:1][C:2]1[C:3]([O:22][C:17]2[CH:18]=[CH:19][CH:20]=[CH:21][C:16]=2[N+:13]([O-:15])=[O:14])=[N:4][CH:5]=[C:6]([C:8]([F:11])([F:10])[F:9])[CH:7]=1

Participants

3

Reactant 2

HCID 69472-NitrophenolHCID 12680753-Chloro-2-fluoro-5-(trifluoromethyl)pyridine

Product 1

HCID 150175302-(3-Chloro-5-trifluoromethyl-2-pyridyloxy)nitrobenzeneYield 63%

Procedure

This material was prepared in 63% yield from 3-chloro-2-fluoro-5-trifluoromethylpyridine and 2-nitrophenol following the general procedure outlined in Example 88. The product was isolated as an amber oil which was characterized by IR and 1H NMR spectroscopy.

Workup

  1. customThe product was isolated as an amber oil which

Sources & evidence

ORD record
ord-b71168e52c68431885140760a2375e17
Source dataset
uspto-grants-1988_05
Patent number
US04741764

Reaction notes

Loading…