Hydrochloric Acid → 2-Chloro-5-nitrophenol

Participants

Reaction Steps

A suspension of 131.2 g (0.85 mole) of 2-amino-5-nitrophenol in 400 ml of 36% hydrochloric acid was maintained at a temperature of 10° C. or less with stirring. To this was added dropwise 150 ml of an aqueous solution containing 66.5 g (0.93 mole) of sodium nitrite over a period of about 1 hour. After completion of the dropwise addition, the mixture was further stirred at a temperature not exceeding 10° C. for 1 hour. To this mixture was added 3 g of sulfamic acid to decompose the excess nitrous acid. The suspension was added to 100 ml of a 20% hydrochloric acid aqueous solution containing 17 g of cuprous chloride with stirring. The stirring was continued for 1 hour.

Provenance & Evidence