反应详情

A solution of 2-benzyl-3-chloro-5-methoxy-2H-1,2,4,6-thiatriazine-1,1-dioxide (3.8 g) in methylene chloride (10 ml) is added dropwise to a stirred mixture of p-nitrophenol (1.7 g) and pyridine (2.4 g) in methylene chloride (20 ml). The reaction mixture is heated to reflux for 3 hours, cooled, washed with 3N aqueous HCl and saturated aqueous Na2CO3. The methylene chloride layer is dried over MgSO4, filtered and evaporated in vacuo yielding the desired product as an oil.

1. temperatureThe reaction mixture is heated
2. temperatureto reflux for 3 hours
3. temperaturecooled
4. washwashed with 3N aqueous HCl and saturated aqueous Na2CO3
5. dry with materialThe methylene chloride layer is dried over MgSO4
6. filtrationfiltered
7. customevaporated in vacuo