HuagongsheHuagongshe Chemistry Print Report · For research reference only
Pyridine → HCID 14129775, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Pyridine | HCID 1049 | — |
| Reactant | 2-Thiazolamine, 4-(chloromethyl)-, hydrochloride (1:1) | HCID 73228 | — |
| Reactant | 3,3-Dimethylbutanoyl chloride | HCID 81514 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | HCID 14129775 | HCID 14129775 | 99.3% |
Reaction Steps
To a mixture of 2-amino-4-chloromethylthiazole hydrochloride (5 g), anhydrous pyridine (5 ml) and anhydrous N,N-dimethylformamide (25 ml) was slowly added 3,3-dimethylbutyryl chloride (4.4 g) with stirring at 0° to 3° C. After an hour of stirring, the reaction mixture was poured into ice water. The resulting precipitate was collected, washed with water and dried to give 2-(3,3-dimethylbutyrylamino)-4-chloromethylthiazole (6.62 g).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04742057 |
| Source dataset | uspto-grants-1988_05 |
| ORD ID | ord-618b2eed2d7b4f58a48e9b0a5ff2de16 |
| Source note | uspto-grants-1988_05 |