Sodium borohydride → HCID 14931752, compound

Participants

Reaction Steps

To a solution of 2-acetylamino-4-(2-formylethyl)thiazole (2.49 g) in diisopropyl ether (170 ml) was added sodium borohydride (120 mg) under ice-cooling and stirred for 1 hour at the same temperature. The reaction mixture was concentrated and the residue was purified by column chromatography on silica gel eluting with a mixture of chloroform and methanol (20:1 V/V) to give 2-acetylamino-4-(3-hydroxypropyl)thiazole (1.70 g).

Provenance & Evidence