Hydrochloric Acid → HCID 14129809, compound

Participants

Reaction Steps

To 4-[4-(3-indolyl)piperidinomethyl]-2-(3acetoxypropionylamino)thiazole (1.1 g) were added ethanol (20 ml) and 1N aqueous solution of sodium hydroxide (2.6 ml) and the mixture was stirred at an ambient temperature for 3.5 hours. 1N hydrochloric acid (2.6 ml) was added thereto and ethanol was evaporated. The residue was extracted with a mixture of chloroform and methanol (10:1 V/V) and the extract was dried over magnesium sulfate and concentrated. The residue was purified by column chromatography on silica gel eluting with a mixture of chloroform and methanol (10:1 V/V) to give 4-[4-(3-indolyl)piperidinomethyl]-2(3-hydroxypropionylamino)thiazole (290 mg).

Provenance & Evidence