反应详情

In 24 ml of water and 24 ml of ethanol, 11.6 g of 2-amino-5-mercapto-1,3,4-thiadiazole and 3.8 g of sodium hydroxide were dissolved, 14.0 g of 1-bromohexane was added to this solution, and the mixture was heated to 70°-80° C. and stirred for 3 hours. After cooling, water was added and the mixture was filtered. The residue was washed with water, dried under reduced pressure, and recrystallized from an ethanol/n-hexane (1:1) mixture. Thus 14.5 g of 2-amino-5-hexylthio-1,3,4-thiadiazole was obtained. m.p. 113°-115° C. Yield 77%.

1. temperaturethe mixture was heated to 70°-80° C.
2. temperatureAfter cooling
3. filtrationthe mixture was filtered
4. washThe residue was washed with water
5. customdried under reduced pressure
6. customrecrystallized from an ethanol/n-hexane (1:1) mixture