Water → HCID 14100783, compound

Participants

Reaction Conditions

Reaction Steps

In 240 ml of methanol, 6.3 g of 2-benzylthio-6-ethoxycarbonyl-5H-1,3,4-thiadiazolo[3,2-a]pyrimidin-5-one was dissolved. A suspension of 27.7 g of OXONE® dispersed in 110 ml of water was added to the methanol solution. The mixture was stirred at 60° C. for 2 hours, and was extracted with chloroform after cooling. The organic layer was washed with a sodium thiosulfate solution and water respectively and dried over anhydrous sodium sulfate. The solvent was distilled off. The residue was recrystallized from an acetonitrile/isopropylether (2:1) mixture and 3.3 g of 2-benzylsulfonyl-6-ethoxycarbonyl-5H-1,3,4-thiadiazolo[3,2-a]pyrimidin-5-one was obtained. m.p. 200°-203° C. Yield 49%.

Provenance & Evidence