1-Propenyl-pyrrolidine → Ethyl 5-(4-ethylphenyl)-3-methyl-6-phenylpyridine-2-carboxylate

HRID 12521Notes

Reaction equation

HRID 12521 reaction equation
[CH2:1]([C:3]1[CH:8]=[CH:7][C:6]([C:9]2N=N[C:12]([C:15]([O:17][CH2:18][CH3:19])=[O:16])=[N:11][C:10]=2[C:20]2[CH:25]=[CH:24][CH:23]=[CH:22][CH:21]=2)=[CH:5][CH:4]=1)[CH3:2].[CH:26](N1CCCC1)=[CH:27][CH3:28]>C(Cl)(Cl)Cl>[CH2:1]([C:3]1[CH:8]=[CH:7][C:6]([C:9]2[CH:26]=[C:27]([CH3:28])[C:12]([C:15]([O:17][CH2:18][CH3:19])=[O:16])=[N:11][C:10]=2[C:20]2[CH:25]=[CH:24][CH:23]=[CH:22][CH:21]=2)=[CH:5][CH:4]=1)[CH3:2]

Participants

4

Reactant 2

HCID 5740691-Propenyl-pyrrolidine2×HCID 25033000Ethyl 6-(4-ethyl-phenyl)-5-phenyl-1,2,4-triazine-3-carboxylate2×

Product 1

HCID 68408281Ethyl 5-(4-ethylphenyl)-3-methyl-6-phenylpyridine-2-carboxylate

Reagents, catalysts & solvents 1

HCID 6212ChloroformSolvent

Procedure

Following General Procedure D, ethyl 6-(4-ethylphenyl)-5-phenyl-1,2,4-triazine-3-carboxylate (Compound 13, 200 mg, 0.60 mmol) and crude 1-propenyl-pyrrolidine (Compound 39, 2 g) in CHCl3 (10 ml) were reacted to produce the title compound as a yellow oil.

Workup

  1. customwere reacted

Sources & evidence

ORD record
ord-d5e75070b7ad48b4b69add6eef67c8a6
Source dataset
uspto-grants-2010_06
Patent number
US07728014B2

Reaction notes

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