Thionyl Chloride → HCID 13823482, Verbindung
Reaktionsgleichung
[F:1][C:2]1[CH:3]=[C:4]([CH2:8][N:9]2[C:13](=[O:14])[CH2:12][CH2:11][CH:10]2[C:15]([OH:17])=O)[CH:5]=[CH:6][CH:7]=1.S(Cl)(Cl)=O.[Cl-].[Al+3].[Cl-].[Cl-]>ClCCl>[F:1][C:2]1[CH:7]=[CH:6][C:5]2[C:15](=[O:17])[CH:10]3[CH2:11][CH2:12][C:13](=[O:14])[N:9]3[CH2:8][C:4]=2[CH:3]=1Komponenten
Edukt 3
Produkt 1
Reagenzien, Katalysatoren, Lösungsmittel 1
Reaktionsbedingungen
- Temperatur
- 5 °C
Versuchsvorschrift
To a solution of 50.00 g of (±)-1-[(3-fluorophenyl)methyl]-5-oxo-2-pyrrolidine carboxylic acid in sieve dried dichloromethane (450 ml), 27.48 g of thionyl chloride was added, and the resultant solution was stirred and refluxed for 5 hours. An infrared spectrum of the solution indicated the presence of the acid chloride. After standing overnight at ambient temperature, the solution was chilled to 5° C. and 84 g of aluminum chloride was added in portions with vigorous stirring. The reaction was exothermic and there was a slow evolution of gas. The mixture was stirred at ambient temperature for 3 hours. The reaction was quenched by the addition of ice chips and water. The two phases of the mixture were separated and the aqueous phase was extracted with dichloromethane (4×150 ml). The combined organic phase was dried (Na2SO4) and concentrated to a solid (69.73 g).
Aufarbeitung
- temperaturerefluxed for 5 hours
- customThe reaction was quenched by the addition of ice chips and water
- customThe two phases of the mixture were separated
- extractionthe aqueous phase was extracted with dichloromethane (4×150 ml)
- dry with materialThe combined organic phase was dried (Na2SO4)
- concentrationconcentrated to a solid (69.73 g)
Quellen und Nachweise
- ORD-Eintrag
- ord-04a2f86a20a54ca89fc7d6f2fca3c6f5
- Quelldatensatz
- uspto-grants-1988_05
- Patentnummer
- US04742061
Notizen zur Reaktion
Wird geladen…