Sodium Hydroxide → HCID 14155730, compound

Participants

Reaction Steps

A solution of 17.40 g of sodium hydroxide pellets in 275 ml of water was treated with 131 g of (±)-1-[(2-trifluoromethylphenyl)methyl]-5-methoxycarbonyl-2-pyrrolidinone and was heated for four hours with a steam bath. The solution was cooled down to room temperature and extracted with diethyl ether (total volume=1000 ml). The aqueous phase was acidified with 50 ml of concentrated hydrochloric acid and extracted with dichloromethane (total volume=900 ml). The organic phase was dried over anhydrous sodium sulfate and concentrated to a solid. The solid was recrystallized from toluene (800 ml) which afforded 49.8 g of crystals, m.p. 139°-141°.

Provenance & Evidence