Propanoyl bromide, 2-bromo- → HCID 20140977, compound

Participants

Reaction Steps

A solution of 15.0 g of 1,2,3,4-tetrahydrobenzo[c]-1,5-naphthyridine in 24 ml of 2-bromopropionyl bromide was stirred overnight at ambient temperature. The solution was then diluted with anhydrous diethyl ether and stirred for approximately 3 hours at ambient temperature. A precipitate separated from the solution. The precipitate was collected by vacuum filtration and dried under vacuum at 40° C. overnight. The solid was recrystallized from a mixture of 95% ethanol and anhydrous diethyl ether (1:2) to yield 28.22 g of a powdery solid.

Provenance & Evidence