Benzene → HCID 14155735, compound

HRID 1252150Notes

Reaction equation

HRID 1252150 reaction equation
[CH3:1][NH:2][C:3]([NH2:5])=[O:4].COC1[CH:9]=[C:10]([CH2:16][C:17](N)=O)[CH:11]=[CH:12]C=1OC.[CH:20]1C=CC=CC=1>>[CH3:1][NH:2][C:3]([N:5]1[CH:12]=[CH:11][C:10]([CH3:9])([CH3:20])[CH:16]=[CH:17]1)=[O:4]

Participants

4

Reactant 3

HCID 241BenzeneHCID 11719MethylureaHCID 797463,4-Dimethoxyphenylacetamide

Product 1

HCID 14155735HCID 14155735, compound

Procedure

The title compound was prepared using the method of Example 2b after substituting an equivalent amount of methylurea for (3,4-dimethoxyphenyl)acetamide as a starting material and diluting the solution three-fold with benzene. The crude product was purified by silica gel flash chromatography eluting with a 25% ethyl acetate/hexane solution. The eluate was evaporated in vacuo to yield the title compound as a white solid, mp 129°-131° C.

Workup

  1. customThe title compound was prepared
  2. customThe crude product was purified by silica gel flash chromatography
  3. washeluting with a 25% ethyl acetate/hexane solution
  4. customThe eluate was evaporated in vacuo

Sources & evidence

ORD record
ord-52d620d5c71c417cb48b3dc3c6b12fbf
Source dataset
uspto-grants-1988_05
Patent number
US04742068

Reaction notes

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