反应详情

5 cc of 85% aqueous sulfuric acid was added to 0.31 g of N-(1,3,5-trimethylpyrazole-4-yl carbonyl)-2,2,4-trimethyl-1,2,3,4-tetrahydroquinoline at room temperature, followed by stirring at the same temperature for 24 hours. The reaction mixture was poured into ice water. The precipitated crystal was filtered and washed with n-hexane. After being dried, the crystal was recrystallized from n-hexane-ethyl acetate to obtain 0.17 g of the objective 1,3,5-trimethyl-N-(1,1,3-trimethylindane-4-yl)pyrazole-4-carboxamide.

1. filtrationThe precipitated crystal was filtered
2. washwashed with n-hexane
3. customAfter being dried
4. customthe crystal was recrystallized from n-hexane-ethyl acetate