Water → HCID 13576825, compound

Participants

Reaction Conditions

Reaction Steps

To a stirred solution of the 9-methyl ester (Example 14) (0.365 g) in dry methanol (4 cm3) under anhydrous conditions was added sodium borohydride (0.252 g) causing vigorous effervescence. After 2 hours further sodium borohydride (0.067 g) was added. After the initial effervescence had subsided the reaction was heated to 60° C. Reaction was indicated to be complete and after 4 hours water (4 cm3) was carefully added and the cloudy mixture allowed to cool to room temperature. The product was extracted from the aqueous solution with chloroform, the combined extract washed with water (50 cm3), dried and evaporated under vacuum to yield the title compound as a yellow-white foam, m.p. 124°-127° C.

Provenance & Evidence