HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1252210Generated: November 3, 2026
Sodium borohydride → 1-(p-Nitrobenzyloxycarbonyl)-4-hydroxypiperidine
https://huagongshe.com/reaction/1252210
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Sodium borohydride | HCID 4311764 | — |
| Reactant | (4-Nitrophenyl)methyl 4-oxopiperidine-1-carboxylate | HCID 13292708 | — |
| Solvent | Methanol | HCID 887 | — |
| Solvent | Water | HCID 962 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Product | 1-(p-Nitrobenzyloxycarbonyl)-4-hydroxypiperidine | HCID 13292709 | — |
Reaction Steps
To a mixture of 1-(p-nitrobenzyloxycarbonyl)-4-piperidone (5.46 g) in methanol (54 ml) and tetrahydrofuran (27 ml) was added sodium borohydride (373 mg), followed by stirring at 0° C. for 10 minutes. The reaction mixture was diluted with water and extracted with ethyl acetate. The extract was washed with water, dried over anhydrous sodium sulfate and evaporated to give 1-(p-nitrobenzyloxycarbonyl)-4-hydroxypiperidine.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US04742052 |
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| Source dataset | uspto-grants-1988_05 |
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| ORD ID | ord-c74d4f4b9c614aca92a06654fb514af9 |
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| Source note | uspto-grants-1988_05 |
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