HuagongsheHuagongshe Chemistry Print Report · For research reference only
Isopropanol → 1,4-Dihydro-2,6-dimethyl-5-[(dimethylsulfamoyl)acetyl]-4-(3-nitrophenyl)nicotinic acid methyl ester
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Isopropanol | HCID 3776 | — |
| Reactant | Dimethylformamide | HCID 6228 | — |
| Reactant | 3-Nitrobenzylideneacetoacetic acid methyl ester | HCID 53443010 | — |
| Reactant | 4-amino-N,N-dimethyl-2-oxo-3-pentenesulfonamide | HCID 73663805 | — |
| Solvent | Ethanol | HCID 702 | — |
| Product | 1,4-Dihydro-2,6-dimethyl-5-[(dimethylsulfamoyl)acetyl]-4-(3-nitrophenyl)nicotinic acid methyl ester | HCID 70046641 | — |
Reaction Steps
After boiling 2.5 g of 3-nitrobenzylidene-acetoacetic acid methyl ester and 2.06 g of 4-amino-N,N-dimethyl-2-oxo-3-pentenesulfonamide is a mixture of 10 ml of isopropanol and 5 ml of dimethylformamide for 6 hours there were obtained 2.3 g of 1,4-dihydro-2,6-dimethyl-5-[(dimethylsulfamoyl)acetyl]-4-(3-nitrophenyl)nicotinic acid methyl ester of melting point 154°-157° (yellow crystalline powder from ethanol).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04742069 |
| Source dataset | uspto-grants-1988_05 |
| ORD ID | ord-5988f0e3c6094f8a9e3c90e6860c6df5 |
| Source note | uspto-grants-1988_05 |