Allyl bromide → N-allyl-N-methyl-4-amino-2-oxo-3-pentenesulfonamide

Participants

Reaction Steps

In accordance with the procedure described in Example 7, a solution of 3.8 g of 4-amino-N-methyl-2-oxo-3-pentenesulfonamide and 2.5 ml of allyl bromide in 50 ml of dimethylformamide was treated with 6 g of potassium carbonate and the mixture was stirred intensively at room temperature for 7 hours. The product was firstly chromatographed on 300 g of silica gel with methylene chloride/ethyl acetate (4:1) as the elution agent and then recrystallized from methylene chloride/ether. There were obtained 3.3 g of N-allyl-N-methyl-4-amino-2-oxo-3-pentenesulfonamide in the form of colorless crystals, m.p. 86°-89°.

Provenance & Evidence