Diethyl Ether → HCID 70416749, compound

Participants

Reaction Steps

After boiling 2.8 g of 3-nitrobenzylideneacetoacetic acid isopropyl ester and 2.34 g of 4-amino-N-isopropyl-1-methyl-2-oxo-3-pentenesulfonamide in a mixture of 10 ml of isopropanol and 5 ml of dimethylformamide for 8 hours there were obtained 1.4 g of 1,4-dihydro-2,6-dimethyl-5-[2-(isopropylsulfamoyl)propionyl]-4-(3-nitrophenyl)nicotinic acid isopropyl ester, m.p. 155°-158° (yellow crystalline powder from ether, only one of the two possible racemates).

Provenance & Evidence