Sodium borohydride → HCID 70416825, compound

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Reaction Steps

Analogously to Example 18, 1.86 g of 5-[(ethylsulfamoyl)acetyl]-1,4-dihydro-2,6-dimethyl-4-(3-nitrophenyl)nicotinic acid isopropyl ester were treated with 0.16 g of sodium borohydride in a mixture of 20 ml of isopropanol and 4 ml of dimethylformamide. After chromatography with methylene chloride/ethyl acetate (4:1) as the elution agent there were obtained 1.5 g of 5-[(E)-2-(ethylsulfamoyl)vinyl]-1,4-dihydro-2,6-dimethyl-4-(3-nitrophenyl)nicotinic acid isopropyl ester in the form of yellow crystals, m.p. 187°-189°. Recrystallization from methylene chloride/ether did not increase the melting point.

Provenance & Evidence