Sodium borohydride → HCID 70416706, compound

Participants

Reaction Steps

Analogously to Example 18, a solution of 1.56 g of 1,4-dihydro-5-[(isopropylsulfamoyl)acetyl]-2,6-dimethyl-4-(3-nitrophenyl)nicotinic acid 2,2,2-trifluoroethyl ester in 15 ml of isopropanol was treated with 0.12 g (3 mmol) of sodium borohydride. After chromatography with methylene chloride/ethyl acetate (4:1) as the elution agent there were obtained 1.25 g of 1,4-dihydro-5-[(E)-2-(isopropylsulfamoyl)vinyl]-2,6-dimethyl-4-(3-nitrophenyl)nicotinic acid 2,2,2-trifluoroethyl ester in the form of yellow crystals, m.p. 180°-182°. Recrystallization from isopropanol did not increase the melting point.

Provenance & Evidence