Sodium borohydride → HCID 70045181, compound

Participants

Reaction Steps

Analogously to Example 18, 1.02 g of 4-(2-chloro-5-nitrophenyl)-1,4-dihydro-5-[(isopropylsulfamoyl)acetyl]-2,6-dimethylnicotinic acid isopropyl ester were treated with 0.08 g of sodium borohydride in a mixture of 10 ml of isopropanol and 2 ml of 1,2-dimethoxyethane. After chromatography with methylene chloride/ethyl acetate (4:1) as the elution agent there was obtained 0.70 g of 4-(2-chloro-5-nitrophenyl)-1,4-dihydro-5-[(E)-2-(isopropylsulfamoyl)vinyl]-2,6-dimethylnicotinic acid isopropyl ester in the form of yellow crystals, m.p. 199°-201°.

Provenance & Evidence