Ro 18-3981 → HCID 70416516, compound

Participants

Reaction Steps

Analogously to Example 18, 1.05 g of 1,4-dihydro-5-[(isopropylsulfamoyl)acetyl]-2,6-dimethyl-4-(3-nitrophenyl)nicotinic acid 2-propoxyethyl ester were treated with 0.08 g of sodium borohydride in a mixture of 10 ml of ethanol and 2 ml of dimethylformamide. After chromatography with methylene chloride/ethyl acetate (4:1) as the elution agent there was obtained 0.90 g of 1,4-dihydro-5-[(E)-2-(isopropylsulfamoyl)vinyl]-2,6-dimethyl-4-(3-nitrophenyl)nicotinic acid 2-propoxyethyl ester in the form of yellow crystals, m.p. 152°-154°.

Provenance & Evidence