DL-alpha-Tocopherol → Isopropylidene-5-bromouridine

Beteiligte Stoffe

Reaktionsschritte

The phosphrylation reaction described in Example 1 is repeated except that 4.3 g (0.01 mol) of DL-alpha-tocopherol, 4 g of pyridine, 3.06 g of phosphorus oxychloride, and 50 ml of benzene are used. Separately, 5-bromouridine is treated with p-toluene-sulfonic acid in aceton to give isopropylidene-5-bromouridine and 4.35 g (0.012 mol) of this isopropylidene-5-bromouridine and 2 g of pyridine are dissolved in 60 ml of tetrahydrofuran. Then, the reaction and workup procedures of Example 1 are followed to give the potassium salt and, then, the free acid. The free acid is recrystallized from ethanol to give 2.5 g of colorless crystals melting at 177°-178° C.

Herkunft & Nachweise