反应详情

1.56 g of 1-amidino-4-benzylpiperazine sulfate was added to an ethanol solution containing 0.23 g of sodium hydroxide. To the resulting suspension was added 1.07 g of 1-ethyl-3-methoxymethylenepiperidine-2,4-dione, and they were refluxed for 2 hours. Ethanol was distilled off. Then, water was added and extraction by chloroform was conducted. The chloroform layer was dried and concentrated to obtain 1.4 g of 2-(4-benzylpiperazino)-6-ethyl-5-oxo-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidine with an yield of 69%.

1. temperaturewere refluxed for 2 hours
2. distillationEthanol was distilled off
3. additionThen, water was added
4. extractionextraction by chloroform
5. dry with materialThe chloroform layer was dried
6. concentrationconcentrated